The Neuromuscular junction (NMJ) is the specialized structure between motor nerves and skeletal
muscle, which consisted of presynaptic membrane, synaptic cleft and postsynaptic membrane. This
complex structures converts nerve action potentials into muscle contraction. It is a target of a various
neuroimmunologic disorders due to vulnerable to antibody-mediated attack. The main autoimmune
disorders of NMJ are myasthenia gravis (MG)and Lambert-Eaton myasthenic syndrome (LEMS). The
understanding of the immunological basis of MG and LEMS has improved in the recent years. This review
provides the outline of the anatomy and physiology of the NMJ. It also focuses on recent advance
of immunopathogenesis of NMJ disorder.

KEYWORDS : Neuromuscular junction(NMJ), Myasthenia gravis, Lambert-Eaton myasthenic syndrome, Acetylcholine receptor, Muscle specific kinase(MuSK)