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Korean Journal of Neuromuscular Disorders ; 12 : 1 - 3, December 2020
A Guillain-Barré Syndrome with Anti-GQ1b and Anti-GT1a Antibodies Positivity Manifesting with Acute Bulbar Palsy and Subsequent Delayed Ophthalmoplegia
Down
Seonmin Yoon, MD1 , Jong Seo Bae, MD1 , Byeol-A Yoon, MD2 , Jong Kuk Kim, MD2 , Yerim Kim, MD1 , Sang-Hwa Lee, MD, PhD3, Seonmin Yoon, MD1 , Jong Seo Bae, MD1 , Byeol-A Yoon, MD2 , Jong Kuk Kim, MD2 , Yerim Kim, MD1 , Sang-Hwa Lee, MD, PhD3
Department of Neurology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea 2 Department of Neurology, Dong-A University Hospital, Busan, Korea 3 Department of Neurology, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea

In Guillain-Barré syndrome (GBS) and its variant, anti-GQ1b
antibody has a pathogenic role for ophthalmoplegia. In addition,
anti-GT1a antibody is related with lower cranial nerve involvement.
This report describes a 60-year-old male patient with GBS
manifesting with initially isolated dysphagia and subsequently
developed ophthalmoplegia. Both immunoglobulin G type anti-GQ1b and
anti-GT1a antibodies were detected in the patient¡¯s serum. A
mechanism regarding subsequent involvement of respective cranial
nerves remains to be elucidated.

KEYWORDS : Gangliosides, Bulbar palsy, Ophthalmoplegia

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