A 33-year-old woman, previously diagnosed with multifocal acquired
demyelinating sensory and motor neuropathy, or Lewis-Sumner syndrome
(LSS), presented with diffuse multifocal nerve root swelling
at cervical 3th to 7th resembling with neurofibroma. Upon nerve
conduction investigations, multifocal conduction block in the upper
limb were discovered. In addition, a right mandibular branch of
trigeminal nerve hypertrophy resembling schwannoma was found Treatment
with intravenous immunoglobulin and steroid improved her symptoms. The
observed hypertrophy in the right mandibular branch of the trigeminal
nerve was correlated with her symptoms. This study presents a case of
LSS mimicking neurofibroma with coexisting cranial and peripheral
nerve involvement, emphasizing the usefulness of the magnetic
resonance imaging.

KEYWORDS : Polyradiculoneuropathy, chronic inflammatory demyelinating, Neurofibroma