Rational targets for autoimmune neuromuscular disease have been identified with the progress of
our understanding of the cellular and molecular process underlying autoimmune neuromuscular
disease. Although antigen-specific immunotherapy is not available, effective immunotherapy for
most autoimmune disorders is provided with old and new immunomodulatory treatments, alone or in
combination. The achievements of more specific yet largely experimental therapeutic tools need to
be tested in the human diseases. Here we review the principles and targets of immunotherapy for
autoimmune neuromuscular disorders, applications, and practical guidelines, and give an outlook
on future developments.

KEYWORDS : Immunotherapy,Autoimmune nervous system disease,Neuromuscular diseases