The most prevalent microvascular complication of diabetes mellitus is
neuropathy, which encompasses distal symmetric polyneuropathy,
mononeuropathy, radiculoplexopathy, and autonomic neuropathy.
Intensive glucose control prevents and effectively halts the
progression of diabetic neuropathy in
patients with type 1 diabetes mellitus. However, the effect of strict
glucose control itself is at modest in those with type 2 diabetes.
Although we have better understanding of the mechanism of diabetic
neuropathy, many pharmacologic trials for the targeting underlying
nerve damage have reported
unsuccessful results. In this review, the effects and limitations of
the current therapeutic options will
be discussed.

KEYWORDS : Treatment; Diabetic neuropathies; Life style