The neuromuscular junction is a specialized myoneural synapse that is a target for a variety of disorders
including autoimmune origin. Although myasthenia gravis, the most common autoimmune neuromuscular
junction disorder, is characterized by weakness of muscles that increases with repetitive
use and improves with rest, disorders of the neuromuscular junction have a wide range of clinical
presentations. This frequently poses a diagnostic challenge to clinicians. The exact diagnosis of neuromuscular
junction disorders requires detailed history and physical examination, several pharmacological
methods, neurophysiologic testing, and serologic or immunologic tests. The clinical presentation
determines which diagnostic tests should be used in patients with these disorders.

KEYWORDS : Neuromuscular junction disorders, Diagnosis, Clinical presentation, Pharmacologic methods, Serologic tests